Gordon MP Sir Malcolm Bruce has urged the Prime Minister to intervene to save flights from Aberdeen to London City Airport.
British Airways is removing the link from its timetable from October.
In the Commons, Sir Malcolm sought David Cameron’s support for a campaign to maintain the route.
The MP has teamed up with other cross-party North-east parliamentarians to ask BA to review its decision.
They believe the scrapping of the Aberdeen flights appears to be in order to free up more for Glasgow, Edinburgh and Dublin.
Sir Malcolm asked the Prime Minister to recognise the importance of the route to the North-east economy.
Mr Cameron agreed it was a vital service and that he would investigate.
The Liberal Democrat MP told the Commons: “Removing this air link will be a retrograde step for the North-east economy in reducing the travel options and flexibility available to business and leisure travellers alike.
“It comes at a time when we are looking to see greater improvements in our local infrastructure to match the strengthening local economy.
“I urge British Airways to reconsider their decision.”
In a joint letter with local politicians, Sir Malcolm is seeking assurances from BA officials over the future of the Aberdeen to London City service and has requested a meeting to convey concerns over the moves to axe the link.